F9765
Sigma
Filipin complex from Streptomyces filipinensis
≥70% (UV)
| CAS Number: | 11078-21-0 |
| MDL number: | MFCD00131073 |
Description
| Frequently Asked Questions | Live Chat and Frequently Asked Questions are available for this Product. |
| Biochem/physiol Actions | Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability and associated functions via binding to membrane sterols.1 Filipin binds to membrane sterols such as cholesterol, and it both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.2 |
| Other Notes | Filipin contains 8 isomeric components, with filipin III as the major component. |
Properties
| assay | ≥70% (UV) |
| storage temp. | −20°C |
Safety
Related Products
| Related product | F4767, Filipin III from Streptomyces filipinensis |
References
| Cited Reference | 1. Kawasaki, S., et al., Sterol control of the phosphatidylethanolamine-phosphatidylcholine conversion in the yeast mutant GL7. Proc. Natl. Acad. Sci. U. S. A. 82, 5715-9 , (1985) |
| 2. Marella, M., et al., Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release. J. Biol. Chem. 277, 3737-47, (2002) | |
| Merck | Merck 13,4111 |
